Analysis Type: PANTHER Overrepresentation Test (Released 20240807) Annotation Version and Release Date: GO Ontology database DOI: 10.5281/zenodo.15066566 Released 2025-03-16 Analyzed List: upload_1 (Homo sapiens) Reference List: Homo sapiens (all genes in database) Test Type: FISHER Correction: BONFERRONI Bonferroni count: 9152 GO biological process complete Homo sapiens - REFLIST (20580) upload_1 (129) upload_1 (expected) upload_1 (over/under) upload_1 (fold Enrichment) upload_1 (P-value) heparan sulfate proteoglycan catabolic process (GO:0030200) 10 10 .06 + > 100 6.01E-19 keratan sulfate proteoglycan biosynthetic process (GO:0018146) 16 16 .10 + > 100 1.98E-32 dermatan sulfate proteoglycan metabolic process (GO:0050655) 13 13 .08 + > 100 1.13E-25 dermatan sulfate proteoglycan biosynthetic process (GO:0050651) 9 9 .06 + > 100 1.03E-16 keratan sulfate proteoglycan metabolic process (GO:0042339) 18 18 .11 + > 100 5.93E-37 dermatan sulfate proteoglycan catabolic process (GO:0030209) 4 4 .03 + > 100 1.35E-05 heparan sulfate proteoglycan biosynthetic process (GO:0015012) 30 25 .19 + > 100 9.10E-48 chondroitin sulfate proteoglycan metabolic process (GO:0050654) 30 25 .19 + > 100 9.10E-48 chondroitin sulfate proteoglycan biosynthetic process (GO:0050650) 24 20 .15 + > 100 1.78E-37 ganglioside biosynthetic process via lactosylceramide (GO:0010706) 6 5 .04 + > 100 4.89E-07 hyaluronan biosynthetic process (GO:0030213) 6 5 .04 + > 100 4.89E-07 heparan sulfate proteoglycan metabolic process (GO:0030201) 42 35 .26 + > 100 1.21E-68 glycosaminoglycan biosynthetic process (GO:0006024) 40 33 .25 + > 100 3.86E-64 heparin proteoglycan biosynthetic process (GO:0030210) 11 9 .07 + > 100 5.60E-15 aminoglycan biosynthetic process (GO:0006023) 48 38 .30 + > 100 2.68E-73 heparin proteoglycan metabolic process (GO:0030202) 17 13 .11 + > 100 2.64E-22 proteoglycan catabolic process (GO:0030167) 17 13 .11 + > 100 2.64E-22 proteoglycan biosynthetic process (GO:0030166) 78 59 .49 + > 100 8.35E-116 protein sialylation (GO:1990743) 4 3 .03 + > 100 8.77E-03 hyaluronan catabolic process (GO:0030214) 16 12 .10 + > 100 3.55E-20 chondroitin sulfate proteoglycan catabolic process (GO:0030207) 4 3 .03 + > 100 8.77E-03 proteoglycan metabolic process (GO:0006029) 106 72 .66 + > 100 1.99E-138 glycosaminoglycan metabolic process (GO:0030203) 77 51 .48 + > 100 9.31E-94 poly-N-acetyllactosamine biosynthetic process (GO:0030311) 8 5 .05 + 99.71 4.52E-06 glycosaminoglycan catabolic process (GO:0006027) 26 16 .16 + 98.18 1.00E-25 aminoglycan metabolic process (GO:0006022) 92 56 .58 + 97.11 1.27E-100 hyaluronan metabolic process (GO:0030212) 28 16 .18 + 91.16 5.67E-25 poly-N-acetyllactosamine metabolic process (GO:0030309) 9 5 .06 + 88.63 1.01E-05 aminoglycan catabolic process (GO:0006026) 32 16 .20 + 79.77 1.10E-23 galactose metabolic process (GO:0006012) 13 6 .08 + 73.63 8.17E-07 galactose catabolic process (GO:0019388) 9 4 .06 + 70.90 1.66E-03 N-acetylglucosamine metabolic process (GO:0006044) 19 7 .12 + 58.78 1.40E-07 glycoprotein catabolic process (GO:0006516) 37 13 .23 + 56.05 3.56E-16 ganglioside metabolic process (GO:0001573) 29 9 .18 + 49.51 9.28E-10 ganglioside biosynthetic process (GO:0001574) 17 5 .11 + 46.92 4.77E-04 sulfur compound biosynthetic process (GO:0044272) 149 42 .93 + 44.97 2.18E-55 glucosamine-containing compound metabolic process (GO:1901071) 26 7 .16 + 42.95 1.76E-06 sulfur compound catabolic process (GO:0044273) 47 12 .29 + 40.73 8.66E-13 polysaccharide biosynthetic process (GO:0000271) 25 6 .16 + 38.29 7.93E-05 sulfation (GO:0051923) 21 5 .13 + 37.98 1.54E-03 O-glycan processing (GO:0016266) 39 9 .24 + 36.82 1.86E-08 glycoprotein biosynthetic process (GO:0009101) 281 64 1.76 + 36.34 4.58E-82 glycoprotein metabolic process (GO:0009100) 348 77 2.18 + 35.30 9.28E-101 amino sugar metabolic process (GO:0006040) 43 9 .27 + 33.39 4.85E-08 sulfur compound metabolic process (GO:0006790) 314 59 1.97 + 29.98 2.49E-69 oligosaccharide biosynthetic process (GO:0009312) 27 5 .17 + 29.54 5.92E-03 glycosphingolipid biosynthetic process (GO:0006688) 39 7 .24 + 28.63 3.84E-05 glycosphingolipid metabolic process (GO:0006687) 64 11 .40 + 27.42 1.95E-09 carbohydrate biosynthetic process (GO:0016051) 116 18 .73 + 24.76 2.02E-16 response to antibiotic (GO:0046677) 37 5 .23 + 21.56 3.04E-02 carbohydrate derivative biosynthetic process (GO:1901137) 556 73 3.49 + 20.95 1.00E-76 glycolipid metabolic process (GO:0006664) 107 13 .67 + 19.38 1.25E-09 ceramide biosynthetic process (GO:0046513) 58 7 .36 + 19.25 6.81E-04 liposaccharide metabolic process (GO:1903509) 108 13 .68 + 19.20 1.42E-09 glycolipid biosynthetic process (GO:0009247) 78 9 .49 + 18.41 1.31E-05 ceramide metabolic process (GO:0006672) 99 11 .62 + 17.73 2.75E-07 protein O-linked glycosylation (GO:0006493) 100 11 .63 + 17.55 3.08E-07 oligosaccharide metabolic process (GO:0009311) 64 7 .40 + 17.45 1.36E-03 polysaccharide metabolic process (GO:0005976) 75 8 .47 + 17.02 2.08E-04 protein glycosylation (GO:0006486) 218 23 1.37 + 16.83 6.66E-18 macromolecule glycosylation (GO:0043413) 218 23 1.37 + 16.83 6.66E-18 carbohydrate derivative metabolic process (GO:1901135) 895 92 5.61 + 16.40 3.19E-92 carbohydrate metabolic process (GO:0005975) 442 45 2.77 + 16.24 2.07E-38 carbohydrate derivative catabolic process (GO:1901136) 207 21 1.30 + 16.18 1.05E-15 glycosylation (GO:0070085) 238 23 1.49 + 15.42 5.04E-17 cartilage development (GO:0051216) 179 13 1.12 + 11.59 9.43E-07 sphingolipid metabolic process (GO:0006665) 162 11 1.02 + 10.83 5.59E-05 sphingolipid biosynthetic process (GO:0030148) 106 7 .66 + 10.54 4.30E-02 membrane lipid metabolic process (GO:0006643) 208 13 1.30 + 9.97 6.07E-06 membrane lipid biosynthetic process (GO:0046467) 145 9 .91 + 9.90 3.05E-03 connective tissue development (GO:0061448) 244 13 1.53 + 8.50 4.24E-05 skeletal system development (GO:0001501) 514 24 3.22 + 7.45 1.22E-10 macromolecule biosynthetic process (GO:0009059) 2937 72 18.41 + 3.91 2.43E-24 protein metabolic process (GO:0019538) 3342 79 20.95 + 3.77 6.38E-27 macromolecule catabolic process (GO:0009057) 1057 22 6.63 + 3.32 5.98E-03 biosynthetic process (GO:0009058) 3997 76 25.05 + 3.03 3.94E-19 macromolecule metabolic process (GO:0043170) 5404 91 33.87 + 2.69 6.71E-22 primary metabolic process (GO:0044238) 6778 92 42.49 + 2.17 4.69E-15 system development (GO:0048731) 3629 48 22.75 + 2.11 1.32E-03 metabolic process (GO:0008152) 7642 99 47.90 + 2.07 4.94E-16 multicellular organism development (GO:0007275) 4029 49 25.25 + 1.94 9.75E-03 cellular process (GO:0009987) 15563 125 97.55 + 1.28 3.62E-07 biological_process (GO:0008150) 17724 128 111.10 + 1.15 1.24E-03 regulation of macromolecule metabolic process (GO:0060255) 5709 14 35.79 - .39 3.84E-02 regulation of metabolic process (GO:0019222) 6273 14 39.32 - .36 1.96E-03 regulation of macromolecule biosynthetic process (GO:0010556) 5014 10 31.43 - .32 1.34E-02 regulation of biosynthetic process (GO:0009889) 5195 10 32.56 - .31 5.79E-03 regulation of gene expression (GO:0010468) 4908 9 30.76 - .29 6.29E-03 negative regulation of metabolic process (GO:0009892) 2721 2 17.06 - .12 4.64E-02 Unclassified (UNCLASSIFIED) 2856 1 17.90 - .06 0.00E00